Tau is a candidate gene for chromosome 17 frontotemporal dementia
Abstract Frontotemporal dementia with parkinsonism, chromosome 17 type (FTDP‐17), a recently defined disease entity, is clinically characterized by personality changes sometimes...
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337 publications
Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Process, format, and clinimetric testing plan
Abstract This article presents the revision process, major innovations, and clinimetric testing program for the Movement Disorder Society (MDS)–sponsored revision of the Unified...
Parkinson disease
Parkinson disease (PD) is the most common neurodegenerative movement disorder. In Europe, prevalence and incidence rates for PD are estimated at approximately 108–257/100 000 an...
Benchmarking transposable element annotation methods for creation of a streamlined, comprehensive pipeline
Abstract Background Sequencing technology and assembly algorithms have matured to the point that high-quality de novo assembly is possible for large, repetitive genomes. Current...
Benchmarking the Incidence and Mortality of Severe Sepsis in the United States*
There is substantial variability in incidence and mortality of severe sepsis depending on the method of database abstraction used. A uniform, consistent method is needed for use...
Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders
Among 1402 participants from 3 selected cohorts, plasma P-tau217 discriminated AD from other neurodegenerative diseases, with significantly higher accuracy than established plas...
Analysis of Points of Interests Recommended for Leisure Walk Descriptions
Leisure walking is a physical activity where locomotion through a natural or even urban environment is the goal in itself, e.g., in pursuit of health and wellbeing. In contrast ...
A Survey on Performance Metrics for Object-Detection Algorithms
This work explores and compares the plethora of metrics for the performance evaluation of object-detection algorithms. Average precision (AP),for instance, is a popular metric f...
Variable expression of Parkinson's disease
The DATATOP database, which includes clinical information on 800 patients with early untreated Parkinson's disease (PD), is well suited to explore clinical heterogeneity in PD. ...