U1 snRNP regulates cancer cell migration and invasion in vitro
Abstract Stimulated cells and cancer cells have widespread shortening of mRNA 3’-untranslated regions (3’UTRs) and switches to shorter mRNA isoforms due to usage of more proxima...
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321 publications
Comparative sequence analysis reveals regulation of genes in developing schistosomula of Schistosoma mansoni exposed to host portal serum
Submitted by Nuzia Santos (nuzia.santos@fiocruz.br) on 2018-04-25T13:23:10Z\nNo. of bitstreams: 1\nComparative sequence analysis reveals regulation of genes.pdf: 325103 bytes, c...
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years before the diagnosis of AD dementia. This long “preclinical” phase of AD would provide ...
UniProt: the universal protein knowledgebase in 2021
Abstract The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional inf...
The socio-economic implications of the coronavirus pandemic (COVID-19): A review
The COVID-19 pandemic has resulted in over 4.3 million confirmed cases and over 290,000 deaths globally. It has also sparked fears of an impending economic crisis and recession....
Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer
In patients with previously untreated metastatic nonsquamous NSCLC without EGFR or ALK mutations, the addition of pembrolizumab to standard chemotherapy of pemetrexed and a plat...
Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction
BACKGROUND In patients with type 2 diabetes, inhibitors of sodium-glucose cotransporter 2 (SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through ...