Genome-Wide Mapping of in Vivo Protein-DNA Interactions
In vivo protein-DNA interactions connect each transcription factor with its direct targets to form a gene network scaffold. To map these protein-DNA interactions comprehensively...
Publications
Explore 170 academic publications
Showing 12 of
170 publications
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (...
DNA methylation-based classification of central nervous system tumours
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardiz...
A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants
Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genot...
Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates
The safety and immunogenicity data from this U.S. phase 1 trial of two vaccine candidates in younger and older adults, added to earlier interim safety and immunogenicity data re...
The catalytic decomposition of hydrogen peroxide by iron salts
[ Note by Dr. O. H. Wansbrough-Jones —Shortly before Professor Haber died, he gave the manuscript of this paper to Professor Sir William Pope. The final revision for the press h...
Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 populatio...