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The Association of Changes in Physical-Activity Level and Other Lifestyle Characteristics with Mortality among Men
Beginning moderately vigorous sports activity, quitting cigarette smoking, maintaining normal blood pressure, and avoiding obesity were separately associated with lower rates of...
Prevalence of obesity in the United States, 2009-2010.
The most recent national data on obesity prevalence among U.S. adults, adolescents, and children show that more than one-third of adults and almost 17% of children and adolescen...
Surrogate endpoints in clinical trials: Definition and operational criteria
Abstract I discuss the idea of using surrogate endpoints in the context of clinical trials to compare two or more treatments or interventions in respect to some ‘true’ endpoint,...
Diathesis-stress theories in the context of life stress research: Implications for the depressive disorders.
Advances in the conceptualization and measurement of life stress in the past 2 decades raise several questions concerning traditional diathesis-stress theories of psychopatholog...
In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue
When a chimeric gene encoding a ubiquitin-β-galactosidase fusion protein is expressed in the yeast Saccharomyces cerevisiae , ubiquitin is cleaved off the nascent fusion protein...
COSMIN methodology for evaluating the content validity of patient-reported outcome measures: a Delphi study
BackgroundContent validity is the most important measurement property of a patient-reported outcome measure (PROM) and the most challenging to assess. Our aims were to: (1) deve...
Age and the Explanation of Crime
One of the few facts agreed on in criminology is the age distribution of crime. This fact has been used to criticize social theories of crime causation, to provide the foundatio...
Introduction to the recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Background Criteria for the clinical diagnosis of Alzheimer's disease (AD) were established in 1984. A broad consensus now exists that these criteria should be revised to incorp...