Publications

UCHIME improves sensitivity and speed of chimera detection

Abstract Motivation: Chimeric DNA sequences often form during polymerase chain reaction amplification, especially when sequencing single regions (e.g. 16S rRNA or fungal Interna...

Tissue-based map of the human proteome

Protein expression across human tissues Sequencing the human genome gave new insights into human biology and disease. However, the ultimate goal is to understand the dynamic exp...

Minimap2: pairwise alignment for nucleotide sequences

Abstract Motivation Recent advances in sequencing technologies promise ultra-long reads of ∼100 kb in average, full-length mRNA or cDNA reads in high throughput and genomic cont...

Evolutionary trees from DNA sequences: A maximum likelihood approach

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data

Integrated analysis of multimodal single-cell data

ezSingleCell is an interactive and easy-to-use application for the analysis of multiple single-cell and spatial omics data types for biologists. It combines the best-performing ...

IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era

Abstract IQ-TREE (http://www.iqtree.org, last accessed February 6, 2020) is a user-friendly and widely used software package for phylogenetic inference using maximum likelihood....

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

Integrating single-cell transcriptomic data across different conditions, technologies, and species

The Sequence of the Human Genome

A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp ...

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions