Publications

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We descri...

Velvet: Algorithms for de novo short read assembly using de Bruijn graphs

We have developed a new set of algorithms, collectively called “Velvet,” to manipulate de Bruijn graphs for genomic sequence assembly. A de Bruijn graph is a compact representat...

Sequence and organization of the human mitochondrial genome

MicroRNA expression profiles classify human cancers

The mutational constraint spectrum quantified from variation in 141,456 humans

LAMMPS - a flexible simulation tool for particle-based materials modeling at the atomic, meso, and continuum scales

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

Novel methods improve prediction of species’ distributions from occurrence data

Prediction of species’ distributions is central to diverse applications in ecology, evolution and conservation science. There is increasing electronic access to vast sets of occ...

IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045

DeepWalk

We present DeepWalk, a novel approach for learning latent representations of\nvertices in a network. These latent representations encode social relations in\na continuous vector...

Genome sequencing in microfabricated high-density picolitre reactors

The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly...

The Complete Genome Sequence of <i>Escherichia coli</i> K-12

The 4,639,221–base pair sequence of Escherichia coli K-12 is presented. Of 4288 protein-coding genes annotated, 38 percent have no attributed function. Comparison with five othe...