Phylogeographic studies in plants: problems and prospects
Genetic structuring of plant populations is strongly influenced by both common ancestry and current patterns of interpopulation genetic exchange. The interaction of these two fo...
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496 publications
Cryptogenic Cirrhosis: Clinical Characterization and Risk Factors for Underlying Disease
We characterized 70 consecutive patients with cryptogenic cirrhosis to assess major risks for liver disease. Each patient was reevaluated for past alcohol exposure, scored by th...
fastDNAml: a tool for construction of phylogenetic trees of DNA sequences using maximum likelihood
We have developed a new tool, called fastDNAml, for constructing phylogenetic trees from DNA sequences. The program can be run on a wide variety of computers ranging from Unix w...
Americans View Their Mental Health, 1957
In 1957, the United States Congress established the Joint Commission on Mental Illness and Health to evaluate the nation's resources for coping with both the psychological and e...
Numerical Simulation of Reactive Flow
Reactive flows encompass a broad range of physical phenomena, interacting over many different time and space scales. Such flows occur in combustion, chemical lasers, the earth's...
Markov Chains
Markov chains are central to the understanding of random processes. This is not only because they pervade the applications of random processes, but also because one can calculat...
Training Very Deep Networks
Theoretical and empirical evidence indicates that the depth of neural networks is crucial for their success. However, training becomes more difficult as depth increases, and tra...
Mitochondrial portraits of human populations using median networks.
Abstract Analysis of variation in the hypervariable region of mitochondrial DNA (mtDNA) has emerged as an important tool for studying human evolution and migration. However, att...
The Pathogenesis of Insulin-Dependent Diabetes Mellitus
Insulin-dependent diabetes mellitus (IDDM) is a chronic disorder that results from autoimmune destruction of the insulin-producing pancreatic beta cells. Much has been learned d...
Phylogeny Estimation and Hypothesis Testing Using Maximum Likelihood
One of the strengths of the maximum likelihood method of phylogenetic estimation is the ease with which hypotheses can be formulated and tested. Maximum likelihood analysis of D...
Molecular Mechanisms of Antibody Somatic Hypermutation
Functional antibody genes are assembled by V-D-J joining and then diversified by somatic hypermutation. This hypermutation results from stepwise incorporation of single nucleoti...