Mixed-Effects Models in S and S-PLUS
Mixed-effects models provide a flexible and powerful tool for the analysis of grouped data, which arise in many areas as diverse as agriculture, biology, economics, manufacturin...
Publications
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5,310 publications
We have never been modern
What makes us modern? This is a classic question in philosophy as well as in political science. However it is often raised without including science and technology in its defini...
<i>EGFR</i> Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene EGF...
Primer3—new capabilities and interfaces
Polymerase chain reaction (PCR) is a basic molecular biology technique with a multiplicity of uses, including deoxyribonucleic acid cloning and sequencing, functional analysis o...
Machine learning: a probabilistic perspective
Today's Web-enabled deluge of electronic data calls for automated methods of data analysis. Machine learning provides these, developing methods that can automatically detect pat...
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
Examination of nature's favorite molecules reveals a striking preference for making carbon-heteroatom bonds over carbon-carbon bonds-surely no surprise given that carbon dioxide...
The Amber biomolecular simulation programs
Abstract We describe the development, current features, and some directions for future development of the Amber package of computer programs. This package evolved from a program...
The Structure of Scientific Revolutions.
Journal Article Book Reviews Get access The Structure of Scientific Revolutions. By Thomas S. Kuhn. International Encyclopaedia of Unified Science, Vol. II , No. 2. (Chicago and...
COSMO: a new approach to dielectric screening in solvents with explicit expressions for the screening energy and its gradient
Starting from the screening in conductors, an algorithm for the accurate calculation of dielectric screening effects in solvents is presented, which leads to rather simple expli...
Tandem repeats finder: a program to analyze DNA sequences
A tandem repeat in DNA is two or more contiguous, approximate copies of a pattern of nucleotides. Tandem repeats have been shown to cause human disease, may play a variety of re...
The Li-Ion Rechargeable Battery: A Perspective
Each cell of a battery stores electrical energy as chemical energy in two electrodes, a reductant (anode) and an oxidant (cathode), separated by an electrolyte that transfers th...