Minimap2: pairwise alignment for nucleotide sequences
Abstract Motivation Recent advances in sequencing technologies promise ultra-long reads of ∼100 kb in average, full-length mRNA or cDNA reads in high throughput and genomic cont...
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Framing: Toward Clarification of a Fractured Paradigm
Journal Article Framing: Toward Clarification of a Fractured Paradigm Get access Robert M. Entman Robert M. Entman 1Robert M. Entman is an associate professor of communication s...
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
Functional analysis of large gene lists, derived in most cases from emerging high-throughput genomic, proteomic and bioinformatics scanning approaches, is still a challenging an...
The Pfam Protein Families Database
Pfam is a large collection of protein multiple sequence alignments and profile hidden Markov models. Pfam is available on the World Wide Web in the UK at http://www.sanger.ac.uk...
Harmonizing the Metabolic Syndrome
A cluster of risk factors for cardiovascular disease and type 2 diabetes mellitus, which occur together more often than by chance alone, have become known as the metabolic syndr...
Integrated analysis of multimodal single-cell data
ezSingleCell is an interactive and easy-to-use application for the analysis of multiple single-cell and spatial omics data types for biologists. It combines the best-performing ...
Regularization Paths for Generalized Linear Models via Coordinate Descent.
We develop fast algorithms for estimation of generalized linear models with convex penalties. The models include linear regression, two-class logistic regression, and multinomia...
Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data.
Abstract We present here a framework for the study of molecular variation within a single species. Information on DNA haplotype divergence is incorporated into an analysis of va...