Publications

<tt>BLAT</tt>—The <tt>BLAST</tt>-Like Alignment Tool

Analyzing vertebrate genomes requires rapid mRNA/DNA and cross-species protein alignments. A new tool, BLAT , is more accurate and 500 times faster than popular existing tools f...

Innate Immune Recognition

The innate immune system is a universal and ancient form of host defense against infection. Innate immune recognition relies on a limited number of germline-encoded receptors. T...

Genomic sequencing.

Unique DNA sequences can be determined directly from mouse genomic DNA. A denaturing gel separates by size mixtures of unlabeled DNA fragments from complete restriction and part...

Obesity is associated with macrophage accumulation in adipose tissue

Obesity alters adipose tissue metabolic and endocrine function and leads to an increased release of fatty acids, hormones, and proinflammatory molecules that contribute to obesi...

Agendas, alternatives, and public policies

1. How Does an Idea's Time Come? 2. Participants on the Inside of Government 3. Outside of Government, But Not Just Looking In 4. Processes: Origins, Rationality, Incrementalism...

Qualitative research in health care: Analysing qualitative data

This is the second in a series of three articles Contrary to popular perception, qualitative research can produce vast amounts of data. These may include verbatim notes or tra...

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

Background The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for public health laboratories as virus isolates are unavailable while th...

A novel coronavirus outbreak of global health concern

Construction of <i>Escherichia coli</i> K‐12 in‐frame, single‐gene knockout mutants: the Keio collection

We have systematically made a set of precisely defined, single‐gene deletions of all nonessential genes in Escherichia coli K‐12. Open‐reading frame coding regions were replaced...

The Protein Kinase Complement of the Human Genome

We have catalogued the protein kinase complement of the human genome (the “kinome”) using public and proprietary genomic, complementary DNA, and expressed sequence tag (EST) seq...

We Have Never Been Modern

Reviewed by: We Have Never Been Modern T. Hugh Crawford (bio) Bruno Latour, We Have Never Been Modern. Translated by Catherine Porter. Cambridge, Mass: Harvard University Press,...

Global trends in emerging infectious diseases

Emerging infectious diseases (EIDs) are a significant burden on global economies and public health. Their emergence is thought to be driven largely by socio-economic, environmen...