Publications
Explore 338 academic publications
Accuracy of Clinical Diagnosis in Parkinsonism — A Prospective Study
ABSTRACT: Clinical diagnosis of Parkinson's syndrome (PS) is reasonably easy in most cases but the distinction between different variants of PS may be difficult in early cases. ...
Clinicopathological correlates in frontotemporal dementia
Abstract The term frontotemporal dementia (FTD) encompasses a range of clinical syndromes that are believed not to map reliably onto the spectrum of recognized pathologies. This...
Human amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo
Certain disease states are characterized by disturbances in production, accumulation or clearance of protein. In Alzheimer disease, accumulation of amyloid-beta (Abeta) in the b...
Identifying prodromal Parkinson's disease: Pre‐Motor disorders in Parkinson's disease
Abstract Increasing recognition that Parkinson's disease (PD) may start outside of the substantia nigra has led to a rapidly expanding effort to define prodromal stages of PD, b...
The substantia nigra of the human brain
Parkinson's disease is characterized by massive degeneration of dopamine-containing neurons in the midbrain. However, the vulnerability of these neurons is heterogeneous both ac...
Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
Abstract Brain iron homeostasis is increasingly recognized as a potential target for the development of drug therapies for aging‐related disorders. Dysregulation of iron metabol...
Surveillance nosokomialer Infektionen
Die Krankenhaushygiene hat im Laufe der vergangenen Jahre in Deutschland einen Wandel erfahren. Neben den traditionellen Schwerpunkten der Hygiene nimmt mittlerweile die epidemi...
Improving Elevator Performance Using Reinforcement Learning
This paper describes the application of reinforcement learning (RL) to the difficult real world problem of elevator dispatching. The elevator domain poses a combination of chall...
Low clinical diagnostic accuracy of early vs advanced Parkinson disease
This study provides Class II evidence that a clinical diagnosis of PD identifies patients who will have pathologically confirmed PD with a sensitivity of 88% and specificity of ...