Development and testing of a general amber force field
Abstract We describe here a general Amber force field (GAFF) for organic molecules. GAFF is designed to be compatible with existing Amber force fields for proteins and nucleic a...
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364 publications
Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China
This Viewpoint summarizes key epidemiologic and clinical findings from all cases of coronavirus disease 2019 (COVID-19) reported through February 11, 2020, in mainland China, an...
Compressed sensing
Suppose x is an unknown vector in Ropfm (a digital image or signal); we plan to measure n general linear functionals of x and then reconstruct. If x is known to be compressible ...
Bootstrap Methods: Another Look at the Jackknife
We discuss the following problem: given a random sample $\\mathbf{X} = (X_1, X_2, \\cdots, X_n)$ from an unknown probability distribution $F$, estimate the sampling distribution...
The Knowledge-Creating Company
Abstract How has Japan become a major economic power, a world leader in the automotive and electronics industries? What is the secret of their success? The consensus has been th...
Can Quantum-Mechanical Description of Physical Reality Be Considered Complete?
In a complete theory there is an element corresponding to each element of reality. A sufficient condition for the reality of a physical quantity is the possibility of predicting...
The Art of Case Study Research
Introduction An Intensive Study of Case Study Research Methods The Unique Case Research Questions The Nature of Qualitative Research Data Gathering Analysis and Interpretation C...
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Computational single-cell RNA-seq (scRNA-seq) methods have been successfully applied to experiments representing a single condition, technology, or species to discover and defin...
Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States
The prevalence of psychiatric disorders is greater than previously thought to be the case. Furthermore, this morbidity is more highly concentrated than previously recognized in ...
Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring
Although cancer classification has improved over the past 30 years, there has been no general approach for identifying new cancer classes (class discovery) or for assigning tumo...
Quantifying the Sim-To-Real Gap in UAV Disturbance Rejection
Due to the safety risks and training sample inefficiency, it is often preferred to develop controllers in simulation. However, minor differences between the simulation and the r...