Vascular COX-2 Modulates Blood Pressure and Thrombosis in Mice

Abstract

Deletion of vascular COX-2 predisposes mice to thrombosis and hypertension.

Keywords

ThrombosisMedicineBlood pressureCardiologyInternal medicine

Affiliated Institutions

Related Publications

Prostaglandins and Inflammation

Emanuela Ricciotti , Garret A. FitzGerald

Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain homeostatic functions and mediate pathogenic mechanisms, including the inflammatory response....

2011 Arteriosclerosis Thrombosis and Vascu... 3555 citations

Inflammation and Cancer: Chemical Approaches to Mechanisms, Imaging, and Treatment

Lawrence J. Marnett

The inflammatory response represents a first line of defense against invading pathogens and is important to human health. Chronic inflammation contributes to the etiology of mul...

2012 The Journal of Organic Chemistry 50 citations

The COXIB Experience: A Look in the Rearview Mirror

Lawrence J. Marnett

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used prescription and nonprescription drugs in the world. The discovery of cyclooxygenase (COX) as the t...

2008 The Annual Review of Pharmacology and... 228 citations

Emotion Recollected in Tranquility: Lessons Learned from the COX-2 Saga

Tilo Großer , Ying Yu , Garret A. FitzGerald

Nonsteroidal antinflammatory drugs (NSAIDs) inhibit prostaglandin formation by cyclooxygenases (COX) 1 and 2. NSAIDs selective for inhibition of COX-2 are less likely than tradi...

2010 Annual Review of Medicine 228 citations

Trifluoromethyl Fluorocoxib A Detects Cyclooxygenase-2 Expression in Inflammatory Tissues and Human Tumor Xenografts

Md. Jashim Uddin , Brenda C. Crews , Imran Huda +3 more

Fluorocoxib A is an effective COX-2-targeted optical imaging agent, used for in vivo detection of inflammatory tissues and premalignant and malignant tumors that express elevate...

2014 ACS Medicinal Chemistry Letters 33 citations

Publication Info

Year: 2012
Type: article
Volume: 4
Issue: 132
Pages: 132ra54-132ra54
Citations: 232
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Vascular COX-2 Modulates Blood Pressure and Thrombosis in Mice

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

232

OpenAlex

Cite This

APA Style

                            
                                
                                    Ying Yu, 
                                
                                    Emanuela Ricciotti, 
                                
                                    Rosario Scalia
                                
                                et al.
                            
                            (2012). 
                            Vascular COX-2 Modulates Blood Pressure and Thrombosis in Mice. 
                            Science Translational Medicine
                            , 4
                            (132)
                            , 132ra54-132ra54.
                            https://doi.org/10.1126/scitranslmed.3003787
                        

Identifiers

DOI: 10.1126/scitranslmed.3003787