Keywords
BiologySingle-nucleotide polymorphismHuman genetic variationGenetic variationVariation (astronomy)Human genomeSNPGeneticsSequence (biology)Computational biologyReference genome1000 Genomes ProjectEvolutionary biologyGenomeGeneGenotype
Affiliated Institutions
Related Publications
The diploid genome sequence of an Asian individual
Here we present the first diploid genome sequence of an Asian individual. The genome was sequenced to 36-fold average coverage using massively parallel sequencing technology. We...
Genotype Imputation with Thousands of Genomes
Abstract Genotype imputation is a statistical technique that is often used to increase the power and resolution of genetic association studies. Imputation methods work by using ...
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common di...
A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies
Genotype imputation methods are now being widely used in the analysis of genome-wide association studies. Most imputation analyses to date have used the HapMap as a reference da...
SNP detection and genotyping from low-coverage sequencing data on multiple diploid samples
Reductions in the cost of sequencing have enabled whole-genome sequencing to identify sequence variants segregating in a population. An efficient approach is to sequence many sa...
Publication Info
- Year
- 2001
- Type
- article
- Volume
- 27
- Issue
- 3
- Pages
- 234-236
- Citations
- 909
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
909
OpenAlex
Cite This
Leonid Kruglyak,
Deborah A. Nickerson
(2001).
Variation is the spice of life.
Nature Genetics
, 27
(3)
, 234-236.
https://doi.org/10.1038/85776
Identifiers
- DOI
- 10.1038/85776