Variation in FTO contributes to childhood obesity and severe adult obesity

Abstract

We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.

Keywords

ObesityFTO geneBiologyHaplotypeSingle-nucleotide polymorphismChildhood obesityInternal medicineGeneticsGeneEndocrinologyMedicineAlleleGenotypeOverweight

MeSH Terms

AdiposityAdultAge of OnsetBody CompositionBody Mass IndexCase-Control StudiesChildChromosomesHumanPair 16Cohort StudiesEuropeFemaleGenetic Predisposition to DiseaseGenetic VariationHumansIntronsMaleMiddle AgedObesityPolymorphismSingle Nucleotide

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Publication Info

Year: 2007
Type: article
Volume: 39
Issue: 6
Pages: 724-726
Citations: 1607
Access: Closed

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APA Style

                            
                                
                                    Christian Dina, 
                                
                                    Stephen Eyre, 
                                
                                    Sophie Gallina
                                
                                et al.
                            
                            (2007). 
                            Variation in FTO contributes to childhood obesity and severe adult obesity. 
                            Nature Genetics
                            , 39
                            (6)
                            , 724-726.
                            https://doi.org/10.1038/ng2048
                        

Identifiers

DOI: 10.1038/ng2048
PMID: 17496892

Data Quality

Data completeness: 81%