Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction–Based SARS-CoV-2 Tests by Time Since Exposure

Lauren M. Kucirka; Stephen A. Lauer; Oliver Laeyendecker; Denali Boon; Justin Lessler

doi:10.7326/m20-1495

Abstract

National Institute of Allergy and Infectious Diseases, Johns Hopkins Health System, and U.S. Centers for Disease Control and Prevention.

Keywords

MedicineReverse transcriptaseSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Polymerase chain reactionFalse Negative ReactionsCoronavirus disease 2019 (COVID-19)Predictive valueCoronavirus2019-20 coronavirus outbreakReverse transcription polymerase chain reactionVirologyReal-time polymerase chain reactionInternal medicineImmunologyGeneDiseaseBiologyGenetics

MeSH Terms

Bayes TheoremBetacoronavirusCOVID-19Coronavirus InfectionsFalse Negative ReactionsHumansPandemicsPneumoniaViralReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionRisk FactorsSARS-CoV-2

Affiliated Institutions

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Publication Info

Year: 2020
Type: review
Volume: 173
Issue: 4
Pages: 262-267
Citations: 1537
Access: Closed

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APA Style

                            
                                
                                    Lauren M. Kucirka, 
                                
                                    Stephen A. Lauer, 
                                
                                    Oliver Laeyendecker
                                
                                et al.
                            
                            (2020). 
                            Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction–Based SARS-CoV-2 Tests by Time Since Exposure. 
                            Annals of Internal Medicine
                            , 173
                            (4)
                            , 262-267.
                            https://doi.org/10.7326/m20-1495
                        

Identifiers

DOI: 10.7326/m20-1495
PMID: 32422057
PMCID: PMC7240870

Data Quality

Data completeness: 86%