United Kingdom Prospective Diabetes Study 24: A 6-Year, Randomized, Controlled Trial Comparing Sulfonylurea, Insulin, and Metformin Therapy in Patients...

Abstract

Because initial insulin therapy induced more hypoglycemic reactions and weight gain without necessarily providing better control, it may be reasonable to start with oral agents and change to insulin if goals for glycemic levels are not achieved.

Keywords

MedicineSulfonylureaMetforminType 2 diabetesDiabetes mellitusInternal medicineInsulinRandomized controlled trialUnited Kingdom Prospective Diabetes StudyEndocrinology

Related Publications

High Prevalence of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus and Normal Plasma Aminotransferase Levels

Paola Portillo-Sánchez , Fernando Bril , Maryann Maximos +7 more

Context and Objective: Nonalcoholic fatty liver disease (NAFLD) and its more severe form with steatohepatitis (NASH) are common in patients with type 2 diabetes mellitus (T2DM)....

2015 The Journal of Clinical Endocrinology... 494 citations

Impaired Glucose Tolerance in the U. S. Population

Maureen I Harris

Impaired glucose tolerance (IGT) constitutes two-thirds of all glucose intolerance in the United States and is a major risk factor for diabetes. Despite these findings, the clin...

1989 Diabetes Care 180 citations

Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus.

Orville Kolterman , R S Gray , Justin W. Griffin +4 more

We have assessed the mechanisms involved in the pathogenesis of the insulin resistance associated with impaired glucose tolerance and Type II diabetes mellitus by exploring, by ...

1981 Journal of Clinical Investigation 633 citations

Gene Expression Profile in Skeletal Muscle of Type 2 Diabetes and the Effect of Insulin Treatment

Sreekumar Raghavakaimal , Panagiotis Halvatsiotis , Jill Coenen Schimke +1 more

Type 2 diabetes is characterized by muscle insulin resistance. Nondiabetic first-degree relatives of type 2 diabetic patients have also been reported to have insulin resistance....

2002 Diabetes 256 citations

Non‐alcoholic steatohepatitis: What is it, and why is it important in the Asia–Pacific region?

Geoffrey C. Farrell

Abstract Non‐alcoholic steatohepatitis (NASH), is a critical link in the chain of metabolic fatty liver disorders that spans steatosis to cryptogenic cirrhosis. It is the hepati...

2003 Journal of Gastroenterology and Hepat... 233 citations

Publication Info

Year: 1998
Type: article
Volume: 128
Issue: 3
Pages: 165-175
Citations: 388
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

United Kingdom Prospective Diabetes Study 24: A 6-Year, Randomized, Controlled Trial Comparing Sulfonylurea, Insulin, and Metformin Therapy in Patients with Newly Diagnosed Type 2 Diabetes That Could Not Be Controlled with Diet Therapy

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

388

OpenAlex

Cite This

APA Style

                            
                                
                                    Alex Wright, 
                                
                                    C A Cull, 
                                
                                    Rury R. Holman
                                
                                et al.
                            
                            (1998). 
                            United Kingdom Prospective Diabetes Study 24: A 6-Year, Randomized, Controlled Trial Comparing Sulfonylurea, Insulin, and Metformin Therapy in Patients with Newly Diagnosed Type 2 Diabetes That Could Not Be Controlled with Diet Therapy. 
                            Annals of Internal Medicine
                            , 128
                            (3)
                            , 165-175.
                            https://doi.org/10.7326/0003-4819-128-3-199802010-00001
                        

Identifiers

DOI: 10.7326/0003-4819-128-3-199802010-00001