Unbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses

Ido Amit; Manuel Garber; Nicolas Chevrier; Ana Paula Leite; Yoni Donner; Thomas Eisenhaure; Mitchell Guttman; Jennifer K. Grenier; Weibo Li; Or Zuk; Lisa Schubert; Brian Birditt; Tal Shay; Alon Goren; Xiaolan Zhang; Zachary D. Smith; Raquel P. Deering; Rebecca C. McDonald; Moran N. Cabili; B Bernstein; John L. Rinn; Alex Meissner; David E. Root; Nir Hacohen; Aviv Regev

doi:10.1126/science.1179050

Abstract

Peeking at Pathogen Response Networks Networks controlling gene expression serve as key decision-making circuits in cells, but the regulatory networks that control dynamic and specific gene expression responses to stimuli are often not well understood. This is particularly true for immune dendritic cells (DCs), which respond to pathogens by mounting elaborate transcriptional responses, and are centrally involved in infectious diseases, autoimmunity, and vaccines. Amit et al. (p. 257 , published online 3 September) explored the transcriptional response of dendritic cells to specific classes of pathogens. The transcriptional subnetworks responsible for mammalian dendritic cell responses to different pathogens were identified, and the function of 100 regulators clarified.

Keywords

BiologyChromatinComputational biologyGene regulatory networkTranscriptional regulationRegulation of gene expressionGeneTranscription factorGene expressionCell biologyGenetics

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Publication Info

Year: 2009
Type: article
Volume: 326
Issue: 5950
Pages: 257-263
Citations: 490
Access: Closed

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APA Style

                            
                                
                                    Ido Amit, 
                                
                                    Manuel Garber, 
                                
                                    Nicolas Chevrier
                                
                                et al.
                            
                            (2009). 
                            Unbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses. 
                            Science
                            , 326
                            (5950)
                            , 257-263.
                            https://doi.org/10.1126/science.1179050
                        

Identifiers

DOI: 10.1126/science.1179050