Abstract
The covalent immobilization of antibodies using non-amphiphilic alkylated cellulose films is described—the Figure shows the antibodies attached to the film via imino bonds. Rapid detection of a specific antibody–antigen reaction is demonstrated as is single-molecule detection. Thus biochemical surfaces prepared in this way have great potential as ultrasensitive bio- and immunosensors.
Keywords
Materials scienceCovalent bondCelluloseAmphiphileMoleculeAlkylationCombinatorial chemistryNanotechnologyCatalysisCopolymerPolymerOrganic chemistryChemistry
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Publication Info
- Year
- 1998
- Type
- article
- Volume
- 10
- Issue
- 13
- Pages
- 1005-1009
- Citations
- 36
- Access
- Closed
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Cite This
Frank Löscher,
Thomas Ruckstuhl,
Stefan Seeger
(1998).
Ultrathin Cellulose-Based Layers for Detection of Single Antigen Molecules.
Advanced Materials
, 10
(13)
, 1005-1009.
https://doi.org/10.1002/(sici)1521-4095(199809)10:13<1005::aid-adma1005>3.0.co;2-a
Identifiers
- DOI
- 10.1002/(sici)1521-4095(199809)10:13<1005::aid-adma1005>3.0.co;2-a