Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

Keywords

CarcinogenesisBiologySomatic cellMutationGeneticsDNA replicationMutation ratePhenotypeNeoplastic transformationReplication timingCancer researchGermline mutationDNACancerGene

Affiliated Institutions

Related Publications

Environmental exposures and mutational patterns of cancer genomes

Gerd P. Pfeifer

The etiology of most human cancers is unknown. Genetic inheritance and environmental factors are thought to have major roles, and for some types of cancer, exposure to carcinoge...

2010 Genome Medicine 74 citations

A Hypermutation Phenotype and Somatic <i>MSH6</i> Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy

Chris Hunter , Raffaella Smith , Daniel P. Cahill +52 more

Abstract Malignant gliomas have a very poor prognosis. The current standard of care for these cancers consists of extended adjuvant treatment with the alkylating agent temozolom...

2006 Cancer Research 426 citations

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

Cristian Tomasetti , Lu Li , Bert Vogelstein

A substantial fraction of mutations in human cancer are attributable to random errors occurring during DNA replication.

2017 Science 1078 citations

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

Magali Olivier , Monica Hollstein , Pierre Hainaut

Somatic mutations in the TP53 gene are one of the most frequent alterations in human cancers, and germline mutations are the underlying cause of Li-Fraumeni syndrome, which pred...

2009 Cold Spring Harbor Perspectives in Bi... 2114 citations

Author response: DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

Ben Taylor , Serena Nik‐Zainal , Yee Ling Wu +6 more

Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Me...

2013 4 citations

Publication Info

Year: 1993
Type: article
Volume: 363
Issue: 6429
Pages: 558-561
Citations: 2706
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

2706

OpenAlex

Cite This

APA Style

                            
                                
                                    Yurij Ionov, 
                                
                                    Miguel A. Peinado, 
                                
                                    Sergei Malkhosyan
                                
                                et al.
                            
                            (1993). 
                            Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. 
                            Nature
                            , 363
                            (6429)
                            , 558-561.
                            https://doi.org/10.1038/363558a0
                        

Identifiers

DOI: 10.1038/363558a0