U1 snRNP Determines mRNA Length and Regulates Isoform Expression

Michael G. Berg; Larry N. Singh; Ihab Younis; Qiang Liu; Anna Maria Pinto; Daisuke Kaida; Zhenxi Zhang; Sungchan Cho; Scott Sherrill-Mix; Lili Wan; Gideon Dreyfuss

doi:10.1016/j.cell.2012.05.029

Keywords

BiologyPolyadenylationRNA splicingAlternative splicingExonCell biologyIntronMessenger RNARibonucleoproteinTranscriptomeNonsense-mediated decaysnRNPGene isoformGene expressionGeneMolecular biologyGeneticsRNA

Affiliated Institutions

Related Publications

U1 snRNP regulates cancer cell migration and invasion in vitro

Jung‐Min Oh , Christopher C. Venters , Chao Di +8 more

Abstract Stimulated cells and cancer cells have widespread shortening of mRNA 3’-untranslated regions (3’UTRs) and switches to shorter mRNA isoforms due to usage of more proxima...

2020 Nature Communications 7100 citations

Alternative isoform regulation in human tissue transcriptomes

Eric T. Wang , Rickard Sandberg , Shujun Luo +6 more

Through alternative processing of pre-messenger RNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposin...

2008 Nature 5166 citations

Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1

Jens Lykke‐Andersen , Eileen Wagner

In human cells, a critical pathway in gene regulation subjects mRNAs with AU-rich elements (AREs) to rapid decay by a poorly understood process. AREs have been shown to directly...

2005 Genes & Development 472 citations

Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation

Wencheng Li , Bei You , Mainul Hoque +8 more

Alternative cleavage and polyadenylation (APA) results in mRNA isoforms containing different 3' untranslated regions (3'UTRs) and/or coding sequences. How core cleavage/polyaden...

2015 PLoS Genetics 260 citations

U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation

Daisuke Kaida , Michael G. Berg , Ihab Younis +4 more

2010 Nature 652 citations

Publication Info

Year: 2012
Type: article
Volume: 150
Issue: 1
Pages: 53-64
Citations: 471
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

U1 snRNP Determines mRNA Length and Regulates Isoform Expression

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

471

OpenAlex

Cite This

APA Style

                            
                                
                                    Michael G. Berg, 
                                
                                    Larry N. Singh, 
                                
                                    Ihab Younis
                                
                                et al.
                            
                            (2012). 
                            U1 snRNP Determines mRNA Length and Regulates Isoform Expression. 
                            Cell
                            , 150
                            (1)
                            , 53-64.
                            https://doi.org/10.1016/j.cell.2012.05.029
                        

Identifiers

DOI: 10.1016/j.cell.2012.05.029