Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

Abstract

Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors.

Keywords

AscitesVascular permeabilityIn vitroAscitic fluidPermeability (electromagnetism)SecretionGuinea pigCell cultureChemistryTumor cellsBiologyCell biologyEndocrinologyInternal medicineCancer researchBiochemistryMedicine

Affiliated Institutions

Beth Israel Deaconess Hospital US

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Publication Info

Year: 1983
Type: article
Volume: 219
Issue: 4587
Pages: 983-985
Citations: 3944
Access: Closed

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APA Style

                            
                                
                                    Donald R. Senger, 
                                
                                    Stephen J. Galli, 
                                
                                    Ann M. Dvořàk
                                
                                et al.
                            
                            (1983). 
                            Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid. 
                            Science
                            , 219
                            (4587)
                            , 983-985.
                            https://doi.org/10.1126/science.6823562
                        

Identifiers

DOI: 10.1126/science.6823562