Tissue Factor (Thromboplastin): Localization to Plasma Membranes by Peroxidase-Conjugated Antibodies

Steven M. Zeldis; Yale Nemerson; Frances A. Pitlick; Thomas L. Lentz

doi:10.1126/science.175.4023.766

Abstract

Peroxidase-conjugated antibodies were used to determine the histologic and cytologic localization of bovine and human tissue factor (thromboplastin). Tissue factor antigen was found in highest concentration in the intima of blood vessels, particularly in the plasma membranes of endothelial cells and in human atheromatous plaques. Tissue factor was also found limited to the plasma membranes of many cell types. The presence of tissue factor in the plasma membranes of endothelial cells and atheromata suggests that it may play a significant role in hemostasis and thrombosis.

Keywords

Tissue factorThromboplastinAntibodyHemostasisMembranePathologyPeroxidaseChemistryBiologyImmunologyMolecular biologyCoagulationMedicineBiochemistryInternal medicineEnzyme

MeSH Terms

AnimalsAntigen-Antibody ReactionsAntigensAortaArteriesArteriosclerosisBlood VesselsCattleCell MembraneEpithelial CellsEpitheliumHistocytochemistryHumansLiverLungMyocardiumPeroxidasesPulmonary ArteryRabbitsThromboplastin

Affiliated Institutions

Yale University US

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Publication Info

Year: 1972
Type: article
Volume: 175
Issue: 4023
Pages: 766-768
Citations: 107
Access: Closed

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APA Style

                            
                                
                                    Steven M. Zeldis, 
                                
                                    Yale Nemerson, 
                                
                                    Frances A. Pitlick
                                
                                et al.
                            
                            (1972). 
                            Tissue Factor (Thromboplastin): Localization to Plasma Membranes by Peroxidase-Conjugated Antibodies. 
                            Science
                            , 175
                            (4023)
                            , 766-768.
                            https://doi.org/10.1126/science.175.4023.766
                        

Identifiers

DOI: 10.1126/science.175.4023.766
PMID: 5057816

Data Quality

Data completeness: 81%