Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination

Abstract

Vaccination with ChAdOx1 nCov-19 can result in the rare development of immune thrombotic thrombocytopenia mediated by platelet-activating antibodies against PF4, which clinically mimics autoimmune heparin-induced thrombocytopenia. (Funded by the German Research Foundation.).

Keywords

MedicinePlatelet factor 4ThrombosisHeparin-induced thrombocytopeniaDeep veinPulmonary embolismPlatelet activationHeparinPlateletVaccinationImmunologyInternal medicineVenous thrombosisGastroenterology

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Publication Info

Year: 2021
Type: article
Volume: 384
Issue: 22
Pages: 2092-2101
Citations: 2213
Access: Closed

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APA Style

                            
                                
                                    Andreas Greinacher, 
                                
                                    Thomas Thiele, 
                                
                                    Theodore E. Warkentin
                                
                                et al.
                            
                            (2021). 
                            Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination. 
                            New England Journal of Medicine
                            , 384
                            (22)
                            , 2092-2101.
                            https://doi.org/10.1056/nejmoa2104840
                        

Identifiers

DOI: 10.1056/nejmoa2104840