The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

Keywords

SnailBiologyEpithelial–mesenchymal transitionCadherinMesenchymal stem cellTranscription factorCell biologyDownregulation and upregulationEmbryonic stem cellSNAI1PhenotypeCancer researchCellGeneGenetics

Affiliated Institutions

Related Publications

The Snail genes as inducers of cell movement and survival: implications in development and cancer

Alejandro Barrallo‐Gimeno , M. Ángela Nieto

The functions of the Snail family of zinc-finger transcription factors are essential during embryonic development. One of their best-known functions is to induce epithelial to m...

2005 Development 1369 citations

Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

Thomas Brabletz , Andreas Jung , Simone Reu +5 more

Invasion and dissemination of well-differentiated carcinomas are often associated with loss of epithelial differentiation and gain of mesenchyme-like capabilities of the tumor c...

2001 Proceedings of the National Academy o... 1026 citations

The basics of epithelial-mesenchymal transition

Raghu Kalluri , Robert A. Weinberg

The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly understoo...

2009 Journal of Clinical Investigation 9867 citations

MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents

Dawn R. Cochrane , Nicole S. Spoelstra , Erin N. Howe +2 more

Abstract The transcription factor ZEB1 is normally not expressed in epithelial cells. When inappropriately expressed in carcinomas, ZEB1 initiates epithelial to mesenchymal tran...

2009 Molecular Cancer Therapeutics 312 citations

Morphogenesis of the Polarized Epithelial Cell Phenotype

Enrique Rodríguez-Boulan , W. James Nelson

Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs in mammals. The morphogenesis of a sheet of polarized epithelia...

1989 Science 1082 citations

Publication Info

Year: 2000
Type: article
Volume: 2
Issue: 2
Pages: 76-83
Citations: 3575
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

3575

OpenAlex

Cite This

APA Style

                            
                                
                                    Amparo Cano, 
                                
                                    Mirna Pérez‐Moreno, 
                                
                                    Isabel Rodrigo
                                
                                et al.
                            
                            (2000). 
                            The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression. 
                            Nature Cell Biology
                            , 2
                            (2)
                            , 76-83.
                            https://doi.org/10.1038/35000025
                        

Identifiers

DOI: 10.1038/35000025