The Timing of Early Antibiotics and Hospital Mortality in Sepsis

Abstract

In a large, contemporary, and multicenter sample of patients with sepsis in the emergency department, hourly delays in antibiotic administration were associated with increased odds of hospital mortality even among patients who received antibiotics within 6 hours. The odds increased within each sepsis severity strata, and the increased odds of mortality were greatest in septic shock.

Keywords

MedicineOdds ratioInterquartile rangeSepsisConfidence intervalEmergency departmentAntibioticsSeptic shockLogistic regressionRetrospective cohort studyEmergency medicineInternal medicine

Affiliated Institutions

Related Publications

Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality*

H. Bryant Nguyen , Stephen W. Corbett , R. Steele +6 more

Implementation of a severe sepsis bundle using a quality improvement feedback to modify physician behavior in the emergency department setting was feasible and was associated wi...

2007 Critical Care Medicine 557 citations

Surviving Sepsis Campaign

Mitchell M. Levy , Andrew Rhodes , Gary Phillips +8 more

This analysis demonstrates that increased compliance with sepsis performance bundles was associated with a 25% relative risk reduction in mortality rate. Every 10% increase in c...

2014 Critical Care Medicine 553 citations

Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis

Idris Evans , Gary Phillips , Elizabeth R. Alpern +11 more

In New York State following a mandate for sepsis care, completion of a sepsis bundle within 1 hour compared with not completing the 1-hour sepsis bundle within 1 hour was associ...

2018 JAMA 314 citations

A Randomized Trial of Protocol-Based Care for Early Septic Shock

Donald M. Yealy , John A. Kellum , David T. Huang +9 more

In a multicenter trial conducted in the tertiary care setting, protocol-based resuscitation of patients in whom septic shock was diagnosed in the emergency department did not im...

2014 New England Journal of Medicine 2315 citations

Goal-Directed Resuscitation for Patients with Early Septic Shock

In critically ill patients presenting to the emergency department with early septic shock, EGDT did not reduce all-cause mortality at 90 days. (Funded by the National Health and...

2014 New England Journal of Medicine 1922 citations

Publication Info

Year: 2017
Type: article
Volume: 196
Issue: 7
Pages: 856-863
Citations: 900
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

The Timing of Early Antibiotics and Hospital Mortality in Sepsis

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

900

OpenAlex

Cite This

APA Style

                            
                                
                                    Jean‐Louis Vincent, 
                                
                                    Vikram Fielding‐Singh, 
                                
                                    J Greene
                                
                                et al.
                            
                            (2017). 
                            The Timing of Early Antibiotics and Hospital Mortality in Sepsis. 
                            American Journal of Respiratory and Critical Care Medicine
                            , 196
                            (7)
                            , 856-863.
                            https://doi.org/10.1164/rccm.201609-1848oc
                        

Identifiers

DOI: 10.1164/rccm.201609-1848oc