The reactome pathway knowledgebase 2022

Abstract

Abstract The Reactome Knowledgebase (https://reactome.org), an Elixir core resource, provides manually curated molecular details across a broad range of physiological and pathological biological processes in humans, including both hereditary and acquired disease processes. The processes are annotated as an ordered network of molecular transformations in a single consistent data model. Reactome thus functions both as a digital archive of manually curated human biological processes and as a tool for discovering functional relationships in data such as gene expression profiles or somatic mutation catalogs from tumor cells. Recent curation work has expanded our annotations of normal and disease-associated signaling processes and of the drugs that target them, in particular infections caused by the SARS-CoV-1 and SARS-CoV-2 coronaviruses and the host response to infection. New tools support better simultaneous analysis of high-throughput data from multiple sources and the placement of understudied (‘dark’) proteins from analyzed datasets in the context of Reactome’s manually curated pathways.

Keywords

Affiliated Institutions

• European Bioinformatics Institute GB
• University of Toronto CA
• Dana-Farber Cancer Institute US
• St. John's University US
• Medical University of Vienna AT
• New York University US
• Universidade Federal do Paraná BR
• Oregon Health & Science University US
• Open Targets GB
• Chongqing University of Posts and Telecommunications CN
• Centro Internacional de Entrenamiento e Investigaciones Medicas CO
• Ontario Institute for Cancer Research CA

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