Abstract

IN the 19th century there were two major hypotheses to explain the pathogenesis of atherosclerosis: the "incrustation" hypothesis and the "lipid" hypothesis. The incrustation hypothesis of von Rokitansky,1 proposed in 1852 and modified by Duguid,2 suggested that intimal thickening resulted from fibrin deposition, with subsequent organization by fibroblasts and secondary lipid accumulation. The lipid hypothesis, proposed by Virchow3 in 1856, suggested that lipid in the arterial wall represented a transduction of blood lipid, which subsequently formed complexes with acid mucopolysaccharides; lipid accumulated in arterial walls because mechanisms of lipid deposition predominated over those of removal. The two hypotheses are now . . .

Keywords

PathogenesisMedicineLipid metabolismArterial wallThickeningCoronary heart diseaseCoronary artery diseaseFibrinArteryGlycosaminoglycanPathologyInternal medicineImmunologyAnatomyChemistry

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Year
1992
Type
article
Volume
326
Issue
4
Pages
242-250
Citations
2705
Access
Closed

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Franklin H. Epstein, Valentı́n Fuster, Lina Badimón et al. (1992). The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes. New England Journal of Medicine , 326 (4) , 242-250. https://doi.org/10.1056/nejm199201233260406

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DOI
10.1056/nejm199201233260406