Abstract
AMONG the more remarkable but least understood homeostatic mechanisms of higher organisms are those that govern tissue development, growth and repair. Considering the trillions of cells involved and the complexity and duration of these processes from fertilization until death, it is surprising that functional derangements such as neoplasia do not occur more frequently. Even so, cancer is one of the chief causes of human suffering and death, and, as such, has been the subject of intense research. In animals, such factors as genetic predisposition, viruses, radiation, chemicals, dietary components and hormones are known carcinogens, but they have been conclusively associated . . .
Keywords
Genetic predispositionHormoneMedicineCancerHomeostasisCarcinogenProgrammed cell deathBioinformaticsPhysiologyBiologyCancer researchGeneticsDiseasePathologyInternal medicineApoptosis
Affiliated Institutions
Related Publications
Environment and Cancer: Who Are Susceptible?
Acting in concert with individual susceptibility, environmental factors such as smoking, diet, and pollutants play a role in most human cancer. However, new molecular evidence i...
Nutrition and colorectal cancer
Epidemiologic evidence on the relation between nutrition and colorectal cancer is reviewed. Colon cancer varies approximately 20-fold internationally. Although there is clear ev...
Autophagy and Cell Death
Autophagy is a physiological and evolutionarily conserved phenomenon maintaining homeostatic functions like protein degradation and organelle turnover. It is rapidly upregulated...
Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies
Gastric cancer (GC) is one of the most common malignancies worldwide and it is the fourth leading cause of cancer-related death. GC is a multifactorial disease, where both envir...
Top-down morphogenesis of colorectal tumors
One of the fundamental tenets of oncology is that tumors arise from stem cells. In the colon, stem cells are thought to reside at the base of crypts. In the early stages of tumo...
Publication Info
- Year
- 1974
- Type
- review
- Volume
- 291
- Issue
- 1
- Pages
- 26-35
- Citations
- 209
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
209
OpenAlex
Cite This
Philip J. Fialkow
(1974).
The Origin and Development of Human Tumors Studied with Cell Markers.
New England Journal of Medicine
, 291
(1)
, 26-35.
https://doi.org/10.1056/nejm197407042910109
Identifiers
- DOI
- 10.1056/nejm197407042910109