Abstract
N natural populations, it is expected that there is a constant supply of muta-I tions in each generation.These mutations may have different persistence depending on their fitnesses, but collectively, they constitute the ultimate source of genetic variability in the populations.Since the maintenance of genetic variability is an important subject of study in population genetics, it may be worthwhile to investigate, using various models, the effect of mutation on the genetic variability.For example, KIMURA and CROW (1964) studied the number of alleles maintained in a finite population, assuming that each mutant is an allele not preexisting in the population.
Keywords
BiologyGeneticsHeterozygote advantageMutationPopulationNucleotideFlux (metallurgy)GeneGenotypeDemography
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Publication Info
- Year
- 1969
- Type
- article
- Volume
- 61
- Issue
- 4
- Pages
- 893-903
- Citations
- 869
- Access
- Closed
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Cite This
Makoto Kimura
(1969).
THE NUMBER OF HETEROZYGOUS NUCLEOTIDE SITES MAINTAINED IN A FINITE POPULATION DUE TO STEADY FLUX OF MUTATIONS.
Genetics
, 61
(4)
, 893-903.
https://doi.org/10.1093/genetics/61.4.893
Identifiers
- DOI
- 10.1093/genetics/61.4.893