The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis

H.J.G. Gundersen; Peter V. Bagger; Thomas Fichtner Bendtsen; Stephen M. Evans; Lise Korbo; Niels Marcussen; Arne Möller; Knud Nor Nielsen; J. R. Nyengaard; Bente Pakkenberg; Flemming Brandt Sørensen; A. Vesterby; Mark J. West

doi:10.1111/j.1699-0463.1988.tb00954.x

Abstract

The new stereological methods for correct and efficient sampling and sizing of cells and other particles are reviewed. There is a hierarchy of methods starting from the simplest where even the microscopic magnification may be unknown to the most complex where typically both section thickness and the magnification must be known. Optical sections in suitably modified microscopes can be used to improve the ease and speed with which even the most demanding of these methods are performed. The methods are illustrated by practical examples of applications to a wide range of histological entities including synapses, neurons and cancer cells, glomerular corpuscles and ovarian follicles.

Keywords

StereologyMagnificationSizingComputer scienceRange (aeronautics)Sampling (signal processing)PathologyBiomedical engineeringMaterials scienceArtificial intelligenceChemistryMedicineComputer vision

Affiliated Institutions

Related Publications

Stereology for anisotropic cells: Application to growth cartilage*

Luis M. Cruz‐Orive , Ernst B. Hunziker

SUMMARY A number of either new or recently available stereological methods are described for estimating volume, surface area and number of anisotropic cells. The methods are ill...

1986 Journal of Microscopy 181 citations

Riemann Manifold Langevin and Hamiltonian Monte Carlo Methods

Mark Girolami , Ben Calderhead

Summary The paper proposes Metropolis adjusted Langevin and Hamiltonian Monte Carlo sampling methods defined on the Riemann manifold to resolve the shortcomings of existing Mont...

2011 Journal of the Royal Statistical Soci... 1480 citations

Estimation of Admixture Proportions: A Likelihood-Based Approach Using Markov Chain Monte Carlo

Lounès Chikhi , Michael W. Bruford , Mark Beaumont

Abstract When populations are separated for long periods and then brought into contact for a brief episode in part of their range, this can result in genetic admixture. To analy...

2001 Genetics 119 citations

Energy‐optimized GTO basis sets for LCAO Calculations. A Gradient Approach

Knut Fægri , Jan Almløf

Abstract The use of gradient techniques for the development of energy‐optimized basis sets has been investigated. The region where the energy surface is approximately quadratic ...

1986 Journal of Computational Chemistry 74 citations

A comparison of Bayesian and likelihood-based methods for fitting multilevel models

William J. Browne , David Draper

We use simulation studies, whose design is realistic for educational and medical\nresearch (as well as other fields of inquiry), to compare Bayesian and likelihood-based\nmethod...

2006 Bayesian Analysis 607 citations

Publication Info

Year: 1988
Type: review
Volume: 96
Issue: 7-12
Pages: 857-881
Citations: 2490
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

2490

OpenAlex

Cite This

APA Style

                            
                                
                                    H.J.G. Gundersen, 
                                
                                    Peter V. Bagger, 
                                
                                    Thomas Fichtner Bendtsen
                                
                                et al.
                            
                            (1988). 
                            The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. 
                            Apmis
                            , 96
                            (7-12)
                            , 857-881.
                            https://doi.org/10.1111/j.1699-0463.1988.tb00954.x
                        

Identifiers

DOI: 10.1111/j.1699-0463.1988.tb00954.x