The mouse lymph node as an ectopic transplantation site for multiple tissues

Junji Komori; Lindsey Boone; Aaron D. DeWard; Toshitaka Hoppo; Eric Lagasse

doi:10.1038/nbt.2379

Keywords

Lymph nodeLymphTransplantationImmune systemOrgan transplantationIsletMedicineCancer researchBiologyPathologyImmunologyInternal medicineInsulin

Affiliated Institutions

Related Publications

The human peripheral lymph node vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor.

Ellen L. Berg , M K Robinson , R A Warnock +1 more

The trafficking of lymphocytes from the blood and into lymphoid organs is controlled by tissue-selective lymphocyte interactions with specialized endothelial cells lining post c...

1991 The Journal of Cell Biology 300 citations

Pdx1 ( <i>MODY4</i> ) regulates pancreatic beta cell susceptibility to ER stress

Mira M. Sachdeva , Kathryn Claiborn , Cynthia Khoo +4 more

Type 2 diabetes mellitus (T2DM) results from pancreatic β cell failure in the setting of insulin resistance. Heterozygous mutations in the gene encoding the β cell transcription...

2009 Proceedings of the National Academy o... 218 citations

Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins

Steinunn Bækkeskov , Jens Høiriis Nielsen , B. Marner +3 more

Insulin-dependent diabetic (IDD) patients have a high prevalence of circulating autoantibodies against islet of Langerhans cells at the time of diagnosis1â4. Inflammatory cell...

1982 Nature 534 citations

Accurate Assessment of β-Cell Function

Richard N. Bergman , Marilyn Ader , Katrin Huecking +1 more

Only in the last decade did modeling studies predict, and knockout experiments confirm, that type 2 diabetes is a “2-hit” disease in which insulin resistance is necessarily acco...

2002 Diabetes 506 citations

Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetes

Nathan Lawlor , Joshy George , Mohan Bolisetty +6 more

Blood glucose levels are tightly controlled by the coordinated action of at least four cell types constituting pancreatic islets. Changes in the proportion and/or function of th...

2016 Genome Research 596 citations

Publication Info

Year: 2012
Type: article
Volume: 30
Issue: 10
Pages: 976-983
Citations: 110
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

The mouse lymph node as an ectopic transplantation site for multiple tissues

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

110

OpenAlex

Cite This

APA Style

                            
                                
                                    Junji Komori, 
                                
                                    Lindsey Boone, 
                                
                                    Aaron D. DeWard
                                
                                et al.
                            
                            (2012). 
                            The mouse lymph node as an ectopic transplantation site for multiple tissues. 
                            Nature Biotechnology
                            , 30
                            (10)
                            , 976-983.
                            https://doi.org/10.1038/nbt.2379
                        

Identifiers

DOI: 10.1038/nbt.2379