Abstract
Genes involved in the pathogenesis of cancer are thought to act by two general mechanisms. The first involves the structural alteration of a normal gene (a proto-oncogene) to generate a novel gene (an oncogene) whose protein product acts on the host cell to induce characteristics of malignancy. This protein product is usually involved in cellular proliferation, differentiation, or survival. The second mechanism involves the loss or inactivation of genes whose proteins suppress cancer. Genes of this class are known as tumor-suppressor genes or anti-oncogenes.Alterations in members of specific gene families are consistently associated with some types of leukemia. Table 1 lists . . .
Keywords
GeneOncogeneLeukemiaGene productSuppressorCancerMechanism (biology)Tumor suppressor geneCancer researchBiologyPathogenesisMalignancyGeneticsGene expressionCarcinogenesisImmunologyCell cycle
MeSH Terms
GenesTumor SuppressorGenesrasHumansLeukemiaLeukemiaB-CellLeukemiaT-CellMolecular Probes
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Publication Info
- Year
- 1994
- Type
- review
- Volume
- 330
- Issue
- 5
- Pages
- 328-336
- Citations
- 217
- Access
- Closed
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Cite This
Franklin H. Epstein,
M J Cline
(1994).
The Molecular Basis of Leukemia.
New England Journal of Medicine
, 330
(5)
, 328-336.
https://doi.org/10.1056/nejm199402033300507
Identifiers
- DOI
- 10.1056/nejm199402033300507
- PMID
- 8277954