Abstract

The fms -like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt complementary DNA in COS cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular permeability factor (VEGF-VPF), a factor that induces vascular permeability when injected in the guinea pig skin and stimulates endothelial cell proliferation. Expression of Flt in Xenopus laevis oocytes caused the oocytes to release calcium in response to VEGF-VPF. These findings show that flt encodes a receptor for VEGF-VPF.

Keywords

Vascular endothelial growth factorReceptor tyrosine kinaseTyrosine kinaseVascular endothelial growth factor BCell biologyKinase insert domain receptorROR1Vascular endothelial growth factor APlatelet-derived growth factor receptorXenopusVascular endothelial growth factor CBiologyVascular permeabilityChemistryCancer researchEndocrinologyReceptorGrowth factorVEGF receptorsSignal transductionBiochemistry

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Publication Info

Year
1992
Type
article
Volume
255
Issue
5047
Pages
989-991
Citations
2029
Access
Closed

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Cite This

Carlie de Vries, Jaime A. Escobedo, Hikaru Ueno et al. (1992). The <i>fms</i> -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor. Science , 255 (5047) , 989-991. https://doi.org/10.1126/science.1312256

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DOI
10.1126/science.1312256