Abstract

Interest in the role of the microbiome in human health has burgeoned over the past decade with the advent of new technologies for interrogating complex microbial communities. The large-scale dynamics of the microbiome can be described by many of the tools and observations used in the study of population ecology. Deciphering the metagenome and its aggregate genetic information can also be used to understand the functional properties of the microbial community. Both the microbiome and metagenome probably have important functions in health and disease; their exploration is a frontier in human genetics.

Keywords

MicrobiomeMetagenomicsBiologyHuman healthHuman microbiomeEcologyHuman Microbiome ProjectDiseaseFrontierComputational biologyPopulationEvolutionary biologyData scienceBioinformaticsGeneticsComputer scienceGeographyEnvironmental healthGeneMedicine

MeSH Terms

ArthritisRheumatoidBacteriaColonGastrointestinal TractGenomicsHumansInflammatory Bowel DiseasesLiver DiseasesMetagenomeObesity

Affiliated Institutions

Related Publications

Publication Info

Year
2012
Type
review
Volume
13
Issue
4
Pages
260-270
Citations
3401
Access
Closed

External Links

Download PDF (Free) View on DOI.org PubMed Semantic Scholar

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

3401
OpenAlex
85
Influential
2833
CrossRef

Cite This

Ilseung Cho, Martin J. Blaser (2012). The human microbiome: at the interface of health and disease. Nature Reviews Genetics , 13 (4) , 260-270. https://doi.org/10.1038/nrg3182

Identifiers

DOI
10.1038/nrg3182
PMID
22411464
PMCID
PMC3418802

Data Quality

Data completeness: 90%