The genetics of Crohn disease: Complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives

Wolfgang Küster; Leigh Pascoe; J Purrmann; Spencer Funk; Frank Majewski; John M. Opitz; James F. Reynolds

doi:10.1002/ajmg.1320320122

Abstract

Abstract We have analysed the pedigrees of 265 probands with Crohn disease, collected from a specialty clinic at the University of Düsseldorf. Complex segregation analysis suggests the presence of a recessive gene with incomplete penetrance for susceptibility to the disease with no residual causes of family resemblance. However, a proportion of the isolated cases are probably due to phenocopies, this proportion being greatest among cases with an advanced age of onset.

Keywords

Crohn's diseaseDiseaseMedicineGeneticsCrohn diseaseBiologyInternal medicine

Affiliated Institutions

Related Publications

A clinical genetic study of Parkinson's disease

Alice Lazzarini , Richard H. Myers , Thomas Zimmerman +5 more

We used a family history questionnaire, semi-structured interview, and personal examination of secondary cases to collect data on the prevalence of Parkinson's disease (PD) in r...

1994 Neurology 137 citations

Evidence for a single gene effect causing polycystic ovaries and male pattern baldness

Adam Carey , Kakit Chan , Frances Short +3 more

Summary OBJECTIVE Polycystic ovary syndrome is one of the most common endocrine disorders but its aetiology remains unknown. It is highly prevalent within families, suggesting a...

1993 Clinical Endocrinology 287 citations

Agalactosyl IgG in inflammatory bowel disease: correlation with C-reactive protein.

R K Dube , G.A.W. Rook , J K Steele +4 more

The proportion of oligosaccharide chains on the Fc fragment of IgG which terminate with N-acetylglucosamine (GlcNAc) rather than galactose is increased in rheumatoid arthritis a...

1990 Gut 107 citations

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

Xochitl C. Morgan , Timothy L. Tickle , Harry Sokol +12 more

The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis result from alterations in intestinal microbes and the immune system. However, the precise dysfuncti...

2012 Genome biology 2665 citations

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases

Daniela Parada Venegas , Marjorie K. De la Fuente , Glauben Landskron +6 more

Ulcerative colitis (UC) and Crohn's disease (CD), collectively known as Inflammatory Bowel Diseases (IBD), are caused by a complex interplay between genetic, immunologic, microb...

2019 Frontiers in Immunology 3307 citations

Publication Info

Year: 1989
Type: article
Volume: 32
Issue: 1
Pages: 105-108
Citations: 108
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

The genetics of Crohn disease: Complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

108

OpenAlex

Cite This

APA Style

                            
                                
                                    Wolfgang Küster, 
                                
                                    Leigh Pascoe, 
                                
                                    J Purrmann
                                
                                et al.
                            
                            (1989). 
                            The genetics of Crohn disease: Complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives. 
                            American Journal of Medical Genetics
                            , 32
                            (1)
                            , 105-108.
                            https://doi.org/10.1002/ajmg.1320320122
                        

Identifiers

DOI: 10.1002/ajmg.1320320122