Abstract
A prospective study of 1969 patients with intermittent claudication receiving placebo medication for a minimum of 1 year is reported. Patients were carefully monitored and only four patients were lost to follow-up. Annual mortality was 4.3%. Thirty-six patients developed a definite myocardial infarction, 27 a major stroke, 32 required a major amputation and 111 required surgical or radiological intervention for deteriorating ischaemia of the leg. The entry characteristics of the patients were analysed as a predictor of serious cardiovascular events. The most sensitive predictors of total mortality were age, history of coronary heart disease and an ankle/arm pressure ratio below 0.5. Of the laboratory measurements performed only the initial white cell count was a significant predictor of myocardial infarction, stroke and vascular deaths.
Keywords
MedicineStroke (engine)Myocardial infarctionProspective cohort studyClaudicationAmputationAnkleCardiologyInternal medicineSurgeryPhysical therapyVascular diseaseArterial disease
MeSH Terms
AmputationSurgicalCerebrovascular DisordersDouble-Blind MethodFemaleHumansIntermittent ClaudicationMaleMiddle AgedMyocardial InfarctionPlacebosProportional Hazards ModelsProspective StudiesRisk Factors
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Publication Info
- Year
- 1991
- Type
- article
- Volume
- 5
- Issue
- 2
- Pages
- 131-133
- Citations
- 231
- Access
- Closed
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Cite This
John Dormandy,
Gordon Murray
(1991).
The fate of the claudicant—a prospective study of 1969 claudicants.
European Journal of Vascular Surgery
, 5
(2)
, 131-133.
https://doi.org/10.1016/s0950-821x(05)80676-0
Identifiers
- DOI
- 10.1016/s0950-821x(05)80676-0
- PMID
- 2037083