The evolution of commercial drug delivery technologies

Ava M. Vargason; Aaron C. Anselmo; Samir Mitragotri

doi:10.1038/s41551-021-00698-w

Keywords

Drug deliveryTherapeutic modalitiesDrugDrug developmentSmall moleculeModalitiesTargeted drug deliveryDrug carrierComputational biologyNanotechnologyMedicinePharmacologyChemistryBiologyBiochemistry

Affiliated Institutions

Related Publications

Macromolecular Carrier Systems for Targeted Drug Delivery: Pharmacokinetic Considerations on Biodistribution

Yoshinobu Takakura , Mitsuru Hashida

This review article describes the current status and future perspectives of site-specific drug delivery by means of macromolecular carrier systems. Basic aspects and recent adva...

1996 Pharmaceutical Research 223 citations

Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery

Angela M. Wagner , Margaret P. Gran , Nicholas A. Peppas

Therapeutic proteins and peptides have revolutionized treatment for a number of diseases, and the expected increase in macromolecule-based therapies brings a new set of challeng...

2018 Acta Pharmaceutica Sinica B 137 citations

Progress and challenges towards targeted delivery of cancer therapeutics

Daniel Rosenblum , Nitin Joshi , Wei Tao +2 more

Targeted delivery approaches for cancer therapeutics have shown a steep rise over the past few decades. However, compared to the plethora of successful pre-clinical studies, onl...

2018 Nature Communications 2018 citations

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

Qiang Cheng , Tuo Wei , Lukas Farbiak +3 more

CRISPR–Cas gene editing and messenger RNA-based protein replacement therapy hold tremendous potential to effectively treat disease-causing mutations with diverse cellular origin...

2020 Nature Nanotechnology 1871 citations

Transporter-Guided Delivery of Nanoparticles to Improve Drug Permeation across Cellular Barriers and Drug Exposure to Selective Cell Types

Longfa Kou , Yangzom D. Bhutia , Qing Yao +3 more

Targeted nano-drug delivery systems conjugated with specific ligands to target selective cell-surface receptors or transporters could enhance the efficacy of drug delivery and t...

2018 Frontiers in Pharmacology 287 citations

Publication Info

Year: 2021
Type: review
Volume: 5
Issue: 9
Pages: 951-967
Citations: 1175
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

The evolution of commercial drug delivery technologies

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1175

OpenAlex

Cite This

APA Style

                            
                                    Ava M. Vargason, 
                                
                                    Aaron C. Anselmo, 
                                
                                    Samir Mitragotri
                                
                            (2021). 
                            The evolution of commercial drug delivery technologies. 
                            Nature Biomedical Engineering
                            , 5
                            (9)
                            , 951-967.
                            https://doi.org/10.1038/s41551-021-00698-w

Identifiers

DOI: 10.1038/s41551-021-00698-w