Abstract
Abstract In the biosynthesis of prostaglandin E 1 (PGE 1 ) with an enzyme fraction of sheep vesicular glands glutathione and a moderate amount of antioxidant are required to obtain maximum yield; two oxygen molecules are consumed per mole PGE 1 formed. By altering the incubation conditions, besides PGE 1 various other products can be obtained. A scheme for the mechanism of the conversion is proposed in which the formation of PGE 1 as well as that of the byproducts is assumed to occur on the enzyme in concerted reactions via peroxy‐radicals and a cyclic peroxide.
Keywords
ChemistryIncubationEnzymeGlutathioneProstaglandinAntioxidantRadicalProstaglandin EYield (engineering)BiosynthesisPeroxideBiochemistryStereochemistryOrganic chemistryMaterials science
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Publication Info
- Year
- 1966
- Type
- article
- Volume
- 85
- Issue
- 4
- Pages
- 405-419
- Citations
- 308
- Access
- Closed
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Cite This
D.H. Nugteren,
Rolf Beerthuis,
D. A. van Dorp
(1966).
The enzymic conversion of <i>all</i>‐<i>cis</i> 8,11,14‐eicosatrienoic acid into prostaglandin E<sub>1</sub>.
Recueil des Travaux Chimiques des Pays-Bas
, 85
(4)
, 405-419.
https://doi.org/10.1002/recl.19660850412
Identifiers
- DOI
- 10.1002/recl.19660850412