The Endothelial Glycocalyx Protects Against Myocardial Edema

Bernard M. van den Berg; Hans Vink; Jos A. E. Spaan

doi:10.1161/01.res.0000065917.53950.75

Abstract

Myocardial tissue edema attributable to increased microvascular fluid loss contributes to cardiac dysfunction after myocardial ischemia, cardiopulmonary bypass, hypertension, and sepsis. Recent studies suggest that carbohydrate structures on the luminal surface of microvascular endothelium are essential to prevent tissue edema. We carefully preserved these structures for visualization with electron microscopy, revealing that the rat myocardial capillary endothelial surface is coated with a 0.2- to 0.5-μm-thick carbohydrate layer and that its degradation instantly results in notable myocardial tissue edema.

Keywords

GlycocalyxEdemaEndotheliumMedicinePulmonary edemaEndothelial dysfunctionCardiologyIschemiaTissue fluidInternal medicinePathologyImmunology

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Publication Info

Year: 2003
Type: article
Volume: 92
Issue: 6
Pages: 592-594
Citations: 507
Access: Closed

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APA Style

                            
                                    Bernard M. van den Berg, 
                                
                                    Hans Vink, 
                                
                                    Jos A. E. Spaan
                                
                            (2003). 
                            The Endothelial Glycocalyx Protects Against Myocardial Edema. 
                            Circulation Research
                            , 92
                            (6)
                            , 592-594.
                            https://doi.org/10.1161/01.res.0000065917.53950.75

Identifiers

DOI: 10.1161/01.res.0000065917.53950.75