The effects of rosiglitazone on inflammatory biomarkers and adipokines in diabetic, hypertensive patients.

Milan Gupta; Hwee Teoh; Mahesh Kajil; Michelle Tsigoulis; Adrian Quan; Manoela F.B. Braga; Subodh Verma

Abstract

The present study demonstrated that in hypertensive, diabetic subjects, a rosiglitazone-based treatment strategy results in favourable changes in inflammatory biomarkers compared with metformin/glyburide.

Keywords

MedicineRosiglitazoneAdipokineDiabetes mellitusInternal medicineBioinformaticsEndocrinologyInsulin resistance

Affiliated Institutions

Related Publications

Insulin resistance and cardiovascular disease

Henry N. Ginsberg

Clearly, insulin resistance is not simply a problem of deficient glucose uptake in response to insulin, but a multifaceted syndrome that increases significantly the risk for car...

2000 Journal of Clinical Investigation 1355 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Haiyan Xu , Glenn T. Barnes , Qing Yang +8 more

Insulin resistance arises from the inability of insulin to act normally in regulating nutrient metabolism in peripheral tissues. Increasing evidence from human population studie...

2003 Journal of Clinical Investigation 5594 citations

Insulin Sensitivity and Acute Insulin Response in African-Americans, Non-Hispanic Whites, and Hispanics With NIDDM: The Insulin Resistance Atherosclerosis Study

Steven M. Haffner , George Howard , Elizabeth J Mayer +7 more

NIDDM is usually characterized by β-cell failure decreased and insulin sensitivity. It has been reported that a high proportion of African-American NIDDM subjects are insulin se...

1997 Diabetes 176 citations

Inflammation and insulin resistance

Steven E. Shoelson , Jongsoon Lee , Allison B. Goldfine

Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in diabetic patients. This should have been an important clue to link inflammation to the ...

2006 Journal of Clinical Investigation 4473 citations

Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus

Jerrold M. Olefsky , Orville Kolterman , J A Scarlett

Resistance to the action of insulin can result from a variety of causes, including the formation of abnormal insulin or proinsulin molecules, the presence of circulating antagon...

1982 American Journal of Physiology-Endocr... 277 citations

Publication Info

Year: 2012
Type: article
Volume: 17
Issue: 4
Pages: 191-6
Citations: 2
Access: Closed

External Links

Citation Metrics

OpenAlex

Cite This

APA Style

                            
                                    Milan Gupta, 
                                
                                    Hwee Teoh, 
                                
                                    Mahesh Kajil
                                
                                et al.
                            
                            (2012). 
                            The effects of rosiglitazone on inflammatory biomarkers and adipokines in diabetic, hypertensive patients.. 
                            PubMed
                            , 17
                            (4)
                            , 191-6.