The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure

Abstract

In patients with heart failure and cardiac dyssynchrony, cardiac resynchronization improves symptoms and the quality of life and reduces complications and the risk of death. These benefits are in addition to those afforded by standard pharmacologic therapy. The implantation of a cardiac-resynchronization device should routinely be considered in such patients.

Keywords

MedicineCardiac resynchronization therapyHeart failureCardiologyInternal medicineHazard ratioEjection fractionVentricular dyssynchronyConfidence intervalClinical endpointRandomized controlled trial

Affiliated Institutions

Related Publications

Baseline characteristics of patients recruited into the CARE-HF study

John G.F. Cleland , Jean‐Claude Daubert , Erland Erdmann +5 more

The patients enrolled in CARE-HF had moderately severe heart failure and cardiac dysfunction with evidence of cardiac dyssynchrony. The population appears at high risk of events...

2005 European Journal of Heart Failure 79 citations

The Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial

Bruce L. Wilkoff

Introduction: The devices used to prove the benefit of ICD therapy had only VVI pacing but most current ICD devices provide dual chamber pacing therapy. The DAVID trial sought t...

2003 Pacing and Clinical Electrophysiology 35 citations

The CARE‐HF study (CArdiac REsynchronisation in Heart Failure study): rationale, design and end‐points

John G.F. Cleland , Claude Daubert , Erland Erdmann +5 more

Abstract Background: Cardiac resynchronisation is a promising new intervention for patients with heart failure, left ventricular systolic dysfunction and ventricular dyssynchron...

2001 European Journal of Heart Failure 319 citations

Cardiac Resynchronization Therapy in Heart Failure

Melanie Calvert , Nick Freemantle , John G.F. Cleland

Letters15 February 2005Cardiac Resynchronization Therapy in Heart FailureMelanie Calvert, PhD, Nick Freemantle, PhD, and John G.F. Cleland, MDMelanie Calvert, PhDFrom University...

2005 Annals of Internal Medicine 9 citations

Systematic Review: Cardiac Resynchronization in Patients with Symptomatic Heart Failure

Finlay A. McAlister , Justin A. Ezekowitz , Natasha Wiebe +6 more

In selected patients with heart failure, cardiac resynchronization therapy improves functional and hemodynamic status, reduces heart failure hospitalizations, and reduces all-ca...

2004 Annals of Internal Medicine 318 citations

Publication Info

Year: 2005
Type: article
Volume: 352
Issue: 15
Pages: 1539-1549
Citations: 6169
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

6169

OpenAlex

Cite This

APA Style

                            
                                
                                    John G.F. Cleland, 
                                
                                    Jean‐Claude Daubert, 
                                
                                    Erland Erdmann
                                
                                et al.
                            
                            (2005). 
                            The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure. 
                            New England Journal of Medicine
                            , 352
                            (15)
                            , 1539-1549.
                            https://doi.org/10.1056/nejmoa050496
                        

Identifiers

DOI: 10.1056/nejmoa050496