The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

Abstract

Captopril protects against deterioration in renal function in insulin-dependent diabetic nephropathy and is significantly more effective than blood-pressure control alone.

Keywords

MedicineCaptoprilDiabetic nephropathyNephropathyRenal functionBlood pressureAngiotensin-converting enzymeInternal medicineDiabetes mellitusHypertensive NephropathyEndocrinologyKidneyUrology

Affiliated Institutions

Related Publications

Protection of kidney function and decrease in albuminuria by captopril in insulin dependent diabetics with nephropathy.

H.‐H. Parving , E. Hommel , U. Smidt

STUDY OBJECTIVE--To assess whether long term inhibition of angiotensin converting enzyme with captopril and frusemide or bendrofluazide protects kidney function in diabetic neph...

1988 BMJ 333 citations

Long-Term Stabilizing Effect of Angiotensin-Converting Enzyme Inhibition on Plasma Creatinine and on Proteinuria in Normotensive Type II Diabetic Patients

Mordchai Ravid

In normotensive patients with diabetes mellitus type II, the institution of angiotensin-converting enzyme inhibition during early stages of diabetic nephropathy results in long-...

1993 Annals of Internal Medicine 784 citations

Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes

Edmund J. Lewis , Lawrence G. Hunsicker , William R. Clarke +7 more

The angiotensin-II-receptor blocker irbesartan is effective in protecting against the progression of nephropathy due to type 2 diabetes. This protection is independent of the re...

2001 New England Journal of Medicine 5894 citations

The losartan renal protection study — rationale, study design and baseline characteristics of RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan)

Barry M. Brenner , Mark E. Cooper , Dick de Zeeuw +15 more

The RENAAL Study is a double-blind, placebo-controlled trial to evaluate the renal protective effects of losartan in Type 2 diabetic patients with nephropathy. The study has enr...

2000 Journal of the Renin-Angiotensin-Aldo... 138 citations

Effect of antihypertensive treatment on kidney function in diabetic nephropathy.

Hans‐Henrik Parving , Andreas Andersen , U. Smidt +3 more

The effect of long term, aggressive antihypertensive treatment on kidney function in diabetic nephropathy was studied prospectively in 11 insulin dependent diabetics (mean age 3...

1987 BMJ 548 citations

Publication Info

Year: 1993
Type: article
Volume: 329
Issue: 20
Pages: 1456-1462
Citations: 5366
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

5366

OpenAlex

Cite This

APA Style

                            
                                
                                    Edmund J. Lewis, 
                                
                                    Lawrence G. Hunsicker, 
                                
                                    Raymond P. Bain
                                
                                et al.
                            
                            (1993). 
                            The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy. 
                            New England Journal of Medicine
                            , 329
                            (20)
                            , 1456-1462.
                            https://doi.org/10.1056/nejm199311113292004
                        

Identifiers

DOI: 10.1056/nejm199311113292004