The dTAG system for immediate and target-specific protein degradation

James E. Bradner; Behnam Nabet; Justin M. Roberts; Dennis L. Buckley; Joshiawa Paulk; Shiva Dastjerdi; Annan Yang; Alan L. Leggett; Michael A. Erb; Matthew A. Lawlor; Amanda Souza; Thomas G. Scott; Sarah Vittori; Jennifer A. Perry; Jun Qi; Georg Winter; Kwok‐Kin Wong; Nathanael S. Gray

doi:10.1038/s41589-018-0021-8

Keywords

Computational biologyBiologyDrug discoveryProtein degradationContext (archaeology)BromodomainSystems biologyTransgeneSynthetic biologyCell biologyGeneticsBioinformaticsGeneEpigenetics

Affiliated Institutions

Related Publications

PROTAC targeted protein degraders: the past is prologue

Miklós Békés , David R. Langley , Craig M. Crews

Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to ta...

2022 Nature Reviews Drug Discovery 2520 citations

A New Protein Conjugation System in Human

Noboru Mizushima , Hisao Sugita , Tamotsu Yoshimori +1 more

Autophagy is an intracellular process for bulk degradation of cytoplasmic components. We recently found a protein conjugation system essential for autophagy in the yeast, Saccha...

1998 Journal of Biological Chemistry 489 citations

Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.

Avram Hershko , D Ganoth , Valery Sudakin +5 more

Cyclin B, a positive regulatory subunit of the cdc2 protein kinase complex, is synthesized across the cell cycle and then rapidly degraded at the end of mitosis. Degradation of ...

1994 Journal of Biological Chemistry 233 citations

Cdc53p Acts in Concert with Cdc4p and Cdc34p To Control the G<sub>1</sub>-to-S-Phase Transition and Identifies a Conserved Family of Proteins

Neal Mathias , Stephen L. Johnson , Mark Winey +5 more

Regulation of cell cycle progression occurs in part through the targeted degradation of both activating and inhibitory subunits of the cyclin-dependent kinases. During G1, CDC4,...

1996 Molecular and Cellular Biology 193 citations

Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP).

Mark Rolfe , Peggy Beer‐Romero , Susan Glass +5 more

The E6 protein of the high-risk human papillomaviruses inactivates the tumor suppressor protein p53 by stimulating its ubiquitinylation and subsequent degradation. Ubiquitinylat...

1995 Proceedings of the National Academy o... 116 citations

Publication Info

Year: 2018
Type: article
Volume: 14
Issue: 5
Pages: 431-441
Citations: 1059
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

The dTAG system for immediate and target-specific protein degradation

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1059

OpenAlex

Cite This

APA Style

                            
                                
                                    James E. Bradner, 
                                
                                    Behnam Nabet, 
                                
                                    Justin M. Roberts
                                
                                et al.
                            
                            (2018). 
                            The dTAG system for immediate and target-specific protein degradation. 
                            Nature Chemical Biology
                            , 14
                            (5)
                            , 431-441.
                            https://doi.org/10.1038/s41589-018-0021-8
                        

Identifiers

DOI: 10.1038/s41589-018-0021-8