Abstract

Good bacteria help fight cancer Resident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routy et al. show that antibiotic consumption is associated with poor response to immunotherapeutic PD-1 blockade. They profiled samples from patients with lung and kidney cancers and found that nonresponding patients had low levels of the bacterium Akkermansia muciniphila . Oral supplementation of the bacteria to antibiotic-treated mice restored the response to immunotherapy. Matson et al. and Gopalakrishnan et al. studied melanoma patients receiving PD-1 blockade and found a greater abundance of “good” bacteria in the guts of responding patients. Nonresponders had an imbalance in gut flora composition, which correlated with impaired immune cell activity. Thus, maintaining healthy gut flora could help patients combat cancer. Science , this issue p. 91 , p. 104 , p. 97 ; see also p. 32

Keywords

ImmunotherapyMelanomaMicrobiomeMedicineMetastatic melanomaCancerImmunityImmunologyOncologyCancer immunotherapyImmune systemInternal medicineCancer researchBiologyBioinformatics

MeSH Terms

AnimalsAntibodiesMonoclonalBifidobacterium longumEnterococcus faeciumFecesGastrointestinal MicrobiomeHumansImmunotherapyMelanomaMiceProgrammed Cell Death 1 ReceptorRNARibosomal16SSkin NeoplasmsT-Lymphocytes

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Publication Info

Year
2018
Type
article
Volume
359
Issue
6371
Pages
104-108
Citations
2757
Access
Closed

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Cite This

Vyara Matson, Jessica Fessler, Riyue Bao et al. (2018). The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients. Science , 359 (6371) , 104-108. https://doi.org/10.1126/science.aao3290

Identifiers

DOI
10.1126/science.aao3290
PMID
29302014
PMCID
PMC6707353

Data Quality

Data completeness: 90%