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PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase
Poly(ADP-ribosylation) is a post-translational modification of nuclear proteins in response to DNA damage that activates the base excision repair machinery. Poly(ADP-ribose) pol...
Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination
Cells with non-functional poly(ADP-ribose) polymerase (PARP-1) show increased levels of sister chromatid exchange, suggesting a hyper recombination phenotype in these cells. To ...
The 193-Kd Vault Protein, Vparp, Is a Novel Poly(Adp-Ribose) Polymerase
Mammalian vaults are ribonucleoprotein (RNP) complexes, composed of a small ribonucleic acid and three proteins of 100, 193, and 240 kD in size. The 100-kD major vault protein (...
Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage
DNA-dependent protein kinase (DNA-PK) and poly(ADP-ribose) polymerase (PARP) are activated by DNA strand breaks and participate in DNA repair. We investigated the interactive ef...
Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.
Although specific proteinases play a critical role in the active phase of apoptosis, their substrates are largely unknown. We previously identified poly(ADP-ribose) polymerase (...
Publication Info
- Year
- 2003
- Type
- article
- Volume
- 8
- Issue
- 3
- Pages
- 347-352
- Citations
- 45
- Access
- Closed
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Identifiers
- DOI
- 10.1177/1087057103008003013