Targeting the tumour stroma to improve cancer therapy

Kenneth C. Valkenburg; Amber E. de Groot; Kenneth J. Pienta

doi:10.1038/s41571-018-0007-1

Keywords

StromaMetastasisCancerCancer cellMedicineCancer researchTumor microenvironmentTumour heterogeneityPathologyInternal medicine

Affiliated Institutions

Related Publications

Turning foes to friends: targeting cancer-associated fibroblasts

Xueman Chen , Erwei Song

Current paradigms of cancer-centric therapeutics are usually not sufficient to eradicate the malignancy, as the cancer stroma may prompt tumour relapse and therapeutic resistanc...

2018 Nature Reviews Drug Discovery 1810 citations

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

Dai Fukumura , Jonas Kloepper , Zohreh Amoozgar +2 more

Immunotherapy has emerged as a major therapeutic modality in oncology. Currently, however, the majority of patients with cancer do not derive benefit from these treatments. Vasc...

2018 Nature Reviews Clinical Oncology 1792 citations

Reprogramming of fatty acid metabolism in cancer

Nikos Koundouros , George Poulogiannis

A common feature of cancer cells is their ability to rewire their metabolism to sustain the production of ATP and macromolecules needed for cell growth, division and survival. I...

2019 British Journal of Cancer 1463 citations

Cancer metabolism: looking forward

Inmaculada Martínez‐Reyes , Navdeep S. Chandel

Tumour initiation and progression requires the metabolic reprogramming of cancer cells. Cancer cells autonomously alter their flux through various metabolic pathways in order to...

2021 Nature reviews. Cancer 1648 citations

Targeting Tumor Microenvironment for Cancer Therapy

Catarina Roma‐Rodrigues , Rita Mendes , Pedro V. Baptista +1 more

Cancer development is highly associated to the physiological state of the tumor microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from differ...

2019 International Journal of Molecular Sc... 1134 citations

Publication Info

Year: 2018
Type: review
Volume: 15
Issue: 6
Pages: 366-381
Citations: 1027
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Targeting the tumour stroma to improve cancer therapy

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1027

OpenAlex

Cite This

APA Style

                            
                                    Kenneth C. Valkenburg, 
                                
                                    Amber E. de Groot, 
                                
                                    Kenneth J. Pienta
                                
                            (2018). 
                            Targeting the tumour stroma to improve cancer therapy. 
                            Nature Reviews Clinical Oncology
                            , 15
                            (6)
                            , 366-381.
                            https://doi.org/10.1038/s41571-018-0007-1

Identifiers

DOI: 10.1038/s41571-018-0007-1