Keywords
PI3K/AKT/mTOR pathwaySignalling pathwaysCancerProtein kinase BPaceMedicineSignallingPTENCancer treatmentCancer researchBioinformaticsBiologySignal transductionInternal medicineCell biology
Affiliated Institutions
Related Publications
Phosphatidylinositol 3-Kinase and Xanthine Oxidase Regulate Nitric Oxide and Reactive Oxygen Species Productions by Apoptotic Lymphocyte Microparticles in Endothelial Cells
Abstract Microparticles (MPs) are membrane vesicles released during cell activation and apoptosis. We have previously shown that MPs from apoptotic T cells induce endothelial dy...
Interactions between Wnt and Vg1 signalling pathways initiate primitive streak formation in the chick embryo
The posterior marginal zone (PMZ) of the chick embryo has Nieuwkoop centre-like properties: when transplanted to another part of the marginal zone, it induces a complete embryon...
Publication Info
- Year
- 2009
- Type
- review
- Volume
- 9
- Issue
- 8
- Pages
- 550-562
- Citations
- 2410
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
2410
OpenAlex
Cite This
Jeffrey A. Engelman
(2009).
Targeting PI3K signalling in cancer: opportunities, challenges and limitations.
Nature reviews. Cancer
, 9
(8)
, 550-562.
https://doi.org/10.1038/nrc2664
Identifiers
- DOI
- 10.1038/nrc2664