Keywords
MeSH Terms
Affiliated Institutions
Related Publications
Disruption of the <i>Bcl6</i> Gene Results in an Impaired Germinal Center Formation
The Bcl6 gene has been identified from the chromosomal translocation breakpoint in B cell lymphomas, and its products are expressed highly in germinal center (GC) B cells. To in...
A specific monoclonal antibody (PG-B6) detects expression of the BCL-6 protein in germinal center B cells.
The BCL-6 gene is frequently involved in translocations occurring at the 3q27 locus and is rearranged in approximately 30% of diffuse large cell lymphomas and in a small fractio...
BCL-6 EXPRESSION IN REACTIVE LYMPHOID TISSUE AND IN B-CELL NON-HODGKIN'S LYMPHOMAS
Chromosomal abnormalities involving 3q27 have recently been associated with diffuse large B-cell lymphomas and, less frequently, with follicular lymphomas. Molecular studies hav...
Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6
The gene encoding the BCL-6 transcriptional repressor is frequently translocated and mutated in diffuse large cell lymphoma. Mice with a disrupted BCL-6 gene developed myocardit...
Blockade of Interleukin-6 Signaling Suppresses Not Only Th17 but Also Interphotoreceptor Retinoid Binding Protein–Specific Th1 by Promoting Regulatory T Cells in Experimental Autoimmune Uveoretinitis
PURPOSE. Both Th17 and Th1 cells contribute to experimental autoimmune uveoretinitis (EAU). Interleukin-6 (IL-6) blockade inhibits Th17 differentiation in EAU and potently suppr...
Publication Info
- Year
- 2019
- Type
- review
- Volume
- 50
- Issue
- 5
- Pages
- 1132-1148
- Citations
- 1464
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1016/j.immuni.2019.04.011
- PMID
- 31117010
- PMCID
- PMC6532429