Abstract

We recently reported that the posttraumatic spread of degeneration in the damaged optic nerve can be attenuated by the adoptive transfer of autoimmune T cells specific to myelin basic protein. However, it would be desirable to obtain immune neuroprotection free of any possible autoimmune disease. In an attempt to obtain disease-free immune neuroprotection, we used the synthetic four-amino acid polymer copolymer 1 (Cop-1), which is known not to be encephalitogenic despite its cross-reactivity with myelin basic protein. We show here that active immunization with Cop-1 administered in adjuvant, as well as adoptive transfer of T cells reactive to Cop-1, can inhibit the progression of secondary degeneration after crush injury of the rat optic nerve. These results have implications for the treatment of optic neuropathies.

Keywords

Optic nerveNeuroprotectionAdoptive cell transferMedicineImmune systemMyelinMyelin basic proteinAdjuvantImmunologyNeuroscienceBiologyCentral nervous systemT cellPharmacologyAnatomy

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Year
2000
Type
article
Volume
97
Issue
13
Pages
7446-7451
Citations
308
Access
Closed

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Irun R. Cohen, Michal Schwartz, Jonathan Kipnis et al. (2000). T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: Possible therapy for optic neuropathies. Proceedings of the National Academy of Sciences , 97 (13) , 7446-7451. https://doi.org/10.1073/pnas.97.13.7446

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DOI
10.1073/pnas.97.13.7446